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Advanced Materials: Physicochemical Targeting of Lipid Nanoparticles to the Lungs Induces Clotting: Mechanisms and Solutions


Congratulations to Serena Omo-Lamai and Marco E Zamora for publishing in Advanced Materials!


This study presents compelling evidence that lung-tropic LNPs, whether comprising a cationic charge or a positive zeta potential conferred by ionizable lipid, can instigate extensive thrombosis within pulmonary vasculature. The underlying mechanism involves LNPs binding to fibrinogen, subsequently triggering conformational changes and platelet activation. However, the research also demonstrates that implementing specific anticoagulation techniques and fine-tuning LNP physical properties can effectively mitigate thrombosis while preserving lung-tropic attributes. By elucidating these intricate mechanisms and proposing potential interventions, the study contributes significantly to enhancing the safety and efficacy of targeted drug delivery to the lungs. These findings hold immense promise for advancing nanoparticle-based therapeutics, offering a pathway to overcome challenges associated with clot formation and optimize the development of tailored treatments for respiratory ailments. Furthermore, this research underscores the importance of considering both the physicochemical characteristics of LNPs and their interaction with biological systems to unlock their full potential in medical applications, thereby propelling the frontier of personalized medicine and nanomedicine forward.

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